Src family kinases (SFKs) are a family of non-receptor tyrosine kinases that play a crucial role in signal transduction pathways involved in cell growth, proliferation, differentiation, motility, and survival. SFKs are involved in the regulation of various cellular processes such as cell adhesion, migration, and invasion. Dysregulation of SFK activity has been implicated in the development and progression of various cancers, making them promising targets for cancer therapy. SFKs are composed of nine members, including Src, Fyn, Yes, Lyn, Lck, Hck, Fgr, Blk, and Yrk. Each member has a unique tissue distribution and physiological function, but they all share a common protein structure and domain organization. SFKs are activated by various extracellular stimuli, such as growth factors, cytokines, and integrins, leading to the phosphorylation of downstream signaling molecules and the initiation of specific cellular responses. Research on SFKs has focused on understanding their role in normal cellular function and the mechanisms underlying their activation and regulation. Additionally, there is growing interest in developing SFK inhibitors as potential therapeutic agents for cancer and other diseases characterized by abnormal SFK activity. Overall, research on SFKs continues to provide valuable insights into the molecular mechanisms of cell signaling and their potential as targets for drug development.